Article
Paralytic tremor (pt) rabbit: a sex-linked mutation affecting proteolipid protein-gene expression.
Brain research - 22 Oct 1993
Tosic M, Dolivo M, Amiguet P, Domanska-Janik K, Matthieu J M
Abstract excerpt
Paralytic tremor (pt) is a neurological sex-linked recessive mutation in rabbits which is characterized by a coarse body tremor and limb paresis. Morphological studies showed that this mutation affects CNS myelination. Although the number of oligodendrocytes is not reduced, myelination is slower, irregular and defective. We have made a biochemical and molecular analysis of 4-wk-old mutant and normal rabbits. The...
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