Rabbit paralytic tremor phenotype--a plp1 gene mutation as a model of human Pelizaeus-Merzbacher disease.

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Article

Rabbit paralytic tremor phenotype--a plp1 gene mutation as a model of human Pelizaeus-Merzbacher disease.

Acta neurobiologiae experimentalis - 1 Jan 2005

Sypecka Joanna, Domańska-Janik Krystyna

Abstract excerpt

The paralytic tremor (pt) disease in rabbits results from a point mutation in a plp gene and manifests itself by a broad range of neurological signs. Biochemical studies have shown that myelinogenesis is retarded and deficient in mutant rabbits. Myelin sheaths are usually thin and malformed. The number of oligodendrocytes is normal, however their differentiation and maturation is prolonged. The effects of the pt...

Topics

Animals
Demyelinating Diseases
Disease Models, Animal
Humans
Membrane Proteins
Myelin Proteolipid Protein
Paresis
Pelizaeus-Merzbacher Disease
Phenotype
Point Mutation
Rabbits
Tremor

Source

Open in PubMed

Identifiers

PMID: 15960310

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

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