Article
Many naturally occurring mutations of myelin proteolipid protein impair its intracellular transport
1 Apr 1994
Abstract excerpt
The primary structure of the proteolipid protein (PLP) from the central nervous system (CNS) myelin of mammals is highly conserved with only three amino acid differences between the mouse, rat, dog, bovine, and human proteins. Furthermore, within a particular species no polymorphisms in the protein have been identified. Recent interest has focused on the targeting of PLP in oligodendrocytes and the role that...
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