Article
Polymorphism in AACT gene may lower age of onset of Alzheimer's disease.
Neuroreport - 31 Jan 1996
Talbot C, Houlden H, Craddock N, Crook R, Hutton M, Lendon C, Prihar G, Morris J C, Hardy J, Goate A
Abstract excerpt
The ApoE-epsilon 4 allele is a predisposing factor for late onset Alzheimer's disease (AD), however it is neither necessary nor sufficient to cause the disease. A candidate for explaining part of the remaining genetic component is alpha 1-antichymotrypsin (AACT). In a case-control study we genotyped a polymorphism within the AACT gene to test for association with the disease. No allele of this gene showed an...
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