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Article

Association of serum AACT levels and AACT signal polymorphism with late-onset Alzheimer's disease in Northern Ireland.

International journal of geriatric psychiatry - 1 Mar 2000

McIlroy S P, Vahidassr M D, Savage D A, Lloyd F, Patterson C C, Lawson J T, Passmore A P

Abstract excerpt

alpha1-antichymotrypsin (AACT) is a serine protease inhibitor that has been associated with amyloid plaques in the brains of patients with Alzheimer's disease (AD). It has been reported that AACT serum levels are higher in AD patients than in age and sex matched controls. In addition, polymorphisms in the signal peptide and 5' of the AACT gene have been reported to increase the risk of developing AD. Serum AACT...

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Source

Identifiers

PMID: 10713585
DOI: 10.1002/(sici)1099-1166(200003)15:3<260::aid-gps109>3.0.co;2-m

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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