Apolipoprotein E and alpha1-antichymotrypsin genotypes and age of onset of familial Alzheimer's disease.

doi:10.1159/000017090

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Article

Apolipoprotein E and alpha1-antichymotrypsin genotypes and age of onset of familial Alzheimer's disease.

Dementia and geriatric cognitive disorders - 1 Jan 2000

Axelman K, Basun H, Lannfelt L

Abstract excerpt

Apolipoprotein E (APOE) and alpha1-antichymotrypsin (ACT) genotype and allele frequency distribution were investigated in 113 familial Alzheimer's disease (AD) cases. A significantly higher sigma4 frequency was observed in patients with an age of onset between 55-64 and 65-74 years compared to in...

Topics

Adult
Age of Onset
Aged
Aged, 80 and over
Alleles
Alzheimer Disease
Apolipoproteins E
Female
Gene Frequency
Genotype
Humans
Male
Middle Aged
alpha 1-Antichymotrypsin

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