Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Apolipoprotein E and alpha1-antichymotrypsin genotypes and age of onset of familial Alzheimer's disease.

Dementia and geriatric cognitive disorders - 1 Jan 2000

Axelman K, Basun H, Lannfelt L

Abstract excerpt

Apolipoprotein E (APOE) and alpha1-antichymotrypsin (ACT) genotype and allele frequency distribution were investigated in 113 familial Alzheimer's disease (AD) cases. A significantly higher sigma4 frequency was observed in patients with an age of onset between 55-64 and 65-74 years compared to individuals with later or earlier onset. No difference in ACT A allele frequency was seen in any onset group, nor was any...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Age of Onset
Share to Aged
Share to Aged, 80 and over

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Alleles

Share to Alzheimer Disease

Share to Apolipoproteins E

Share to Gene Frequency

Share to Genotype

Source

Identifiers

PMID: 9844031
DOI: 10.1159/000017090

Genes

APOE

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Apolipoprotein E and alpha1-antichymotrypsin genotypes and age of onset of familial Alzheimer's disease.PMID 9844031Read ↗

Alpha-1-antichymotrypsin (ACT or SERPINA3) polymorphism may affect age-at-onset and disease duration of Alzheimer's disease.Semantic proximity Read ↗

Apolipoprotein E and alpha-1-antichymotrypsin allele polymorphism in sporadic and familial Alzheimer's disease.Semantic proximity Read ↗

Apolipoprotein E and alpha1-antichymotrypsin polymorphism in Alzheimer's disease.Semantic proximity Read ↗

Alpha-antichymotrypsin gene polymorphism and risk for Alzheimer's disease in the Spanish population.Semantic proximity Read ↗

Polymorphism in AACT gene may lower age of onset of Alzheimer's disease.Semantic proximity Read ↗

alpha-1-Antichymotrypsin polymorphism in the gene promoter region affects survival and synapsis loss in Alzheimer's disease.Semantic proximity Read ↗

Apolipoprotein E ε4 Allele Frequency and Age at Onset of Alzheimer’s DiseaseSemantic proximity Read ↗

Apolipoprotein E type 4 allele and Alzheimer's disease: effect on age at onset and relative risk in different age groups.Semantic proximity Read ↗

Apolipoprotein E and Alzheimer's disease: strength of association is related to age at onset.Semantic proximity Read ↗

Apolipoprotein E4 allele and Alzheimer disease: examination of allelic association and effect on age at onset in both early- and late-onset cases.Semantic proximity Read ↗

Polygenic determinants of Alzheimer's disease: modulation of the risk by alpha-1-antichymotrypsin.Semantic proximity Read ↗

Common variants of ACE contribute to variable age-at-onset of Alzheimer's disease.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.