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Article

Restoration of wild-type p53 function in human tumors: strategies for efficient cancer therapy.

Advances in cancer research - 1 Jan 2007

Wiman Klas G

Abstract excerpt

The p53 tumor suppressor gene is mutated in around 50% of all human tumors. Most mutations inactivate p53's specific DNA binding, resulting in failure to activate transcription of p53 target genes. As a consequence, mutant p53 is unable to trigger a p53-dependent biological response, that is cell...

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Identifiers

PMID: 17419952
DOI: 10.1016/S0065-230X(06)97014-6

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-17419952-2026-09-02.1. Manifest publication-graph-cohort-2026-09-02.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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