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Article

HOXB4 Overexpression Promotes Hematopoietic Development by Human Embryonic Stem Cells

13 Jan 2006

Abstract excerpt

Human embryonic stem cells (hESCs) are a potential source of hematopoietic cells for therapeutic transplantation and can provide a model for human hematopoiesis. Culture of hESCs on murine stromal layers or in stromal-free conditions as embryoid bodies results in low levels of hematopoietic cells. Here we demonstrate that overexpression of the transcription factor HOXB4 considerably augments hematopoietic...

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PMID: 16410392
DOI: 10.1634/stemcells.2005-0210

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