Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The transcriptome of the leukemogenic homeoprotein HOXA9 in human hematopoietic cells

11 Nov 2003

Abstract excerpt

Hematopoietic defects in HOXA9(-/-) mice demonstrate a key role for this homeoprotein in blood cell development. Conversely, enforced HOXA9 expression is leukemogenic in mice, and HOXA9 is frequently activated in human acute myeloid leukemia (AML). Although HOXA9 is thought to function as a transcription factor, few downstream targets have been identified. We searched for early HOXA9 target genes by using a...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cancer-related gene regulation
Share to Cell Adhesion Molecules Research
Share to RNA Research and Splicing

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 14604967
DOI: 10.1182/blood-2003-07-2202

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The transcriptome of the leukemogenic homeoprotein HOXA9 in human hematopoietic cellsPMID 14604967Read ↗

The Role of Hox Proteins in Leukemogenesis: Insights Into Key Regulatory Events in HematopoiesisSemantic proximity Read ↗

HOXA9 transcription factor is a double-edged sword: from development to cancer progressionSemantic proximity Read ↗

The Role of the HOXA Gene Family in Acute Myeloid LeukemiaSemantic proximity Read ↗

Pan-cancer exploration of oncogenic and clinical impacts revealed that HOXA9 is a diagnostic indicator of tumorigenesisSemantic proximity Read ↗

Functional interrogation of HOXA9 regulome in MLLr leukemia via reporter-based CRISPR/Cas9 screen.Semantic proximity Read ↗

Functional Interrogation of <i>HOXA9</i> Regulome in MLLr Leukemia via Reporter-based CRISPR/Cas9 screenSemantic proximity Read ↗

Frequent co-expression of the HOXA9 and MEIS1 homeobox genes in human myeloid leukemiasSemantic proximity Read ↗

Isolated Hoxa9 overexpression predisposes to the development of lymphoid but not myeloid leukemia.Semantic proximity Read ↗

<i>HOXA9</i> acts as a regulatory switch in acute myeloid leukaemia and myeloproliferative neoplasmsSemantic proximity Read ↗

HOXA9 has the hallmarks of a biological switch with implications in blood cancers.Semantic proximity Read ↗

RNA-binding protein RBM5 plays an essential role in acute myeloid leukemia by activating the oncogenic protein HOXA9Semantic proximity Read ↗

Candidate Genes for Expansion and Transformation of Hematopoietic Stem Cells by NUP98-HOX Fusion GenesSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.