Article
Reduced sensitivity to saquinavir: an update on genotyping from phase I/II trials.
Antiviral research - 1 Jan 1996
Jacobsen H, Haenggi M, Ott M, Duncan I B, Andreoni M, Vella S, Mous J
Abstract excerpt
A genotypic analysis of the HIV-1 proteinase was performed on clinical specimen obtained from patients after different periods of Saquinavir (SQV) treatment. Proteinase genes of integrated proviral DNA from PBMC were isolated by PCR, cloned and individual sequences were obtained. Genotypic resistance was defined by the Gly48-->Val and Leu90-->Met exchanges. Frequencies and kinetics of resistance development will...
Topics
- Drug Resistance, Microbial
- Genotype
- HIV Infections
- HIV Protease
- HIV Protease Inhibitors
- HIV-1
- Humans
- Isoquinolines
- Mutation
- Quinolines
- Saquinavir