Article
Correlation of response to treatment and HIV genotypic changes during phase III trials with saquinavir and reverse transcriptase inhibitor combination therapy.
AIDS (London, England) - 20 Aug 1998
Race E, Gilbert S M, Sheldon J G, Rose J S, Moffatt A R, Sitbon G, Dissanayeke S R, Cammack N, Duncan I B
Abstract excerpt
OBJECTIVES: Assessment of genotypic change in HIV protease during treatment with saquinavir (SQV) in combination with zidovudine (ZDV) and/or zalcitabine (ddC), to determine the influence of such changes on viral phenotype and response to treatment. DESIGN: Virologic substudies of Phase III clini...
Topics
- Amino Acid Sequence
- DNA, Viral
- Drug Resistance, Microbial
- Drug Therapy, Combination
- Genotype
- HIV
- HIV Infections
- HIV Protease
- HIV Protease Inhibitors
- Humans
- Microbial Sensitivity Tests
- Molecular Sequence Data
- Mutation
- Phenotype