Article
Clinically relevant interpretation of genotype and relationship to plasma drug concentrations for resistance to saquinavir-ritonavir in human immunodeficiency virus type 1 protease inhibitor-experienced patients.
Antimicrobial agents and chemotherapy - 1 Dec 2004
Marcelin Anne-Geneviève, Dalban Cécile, Peytavin Gilles, Lamotte Claire, Agher Rachid, Delaugerre Constance, Wirden Marc, Conan Françoise, Dantin Sylvie, Katlama Christine, Costagliola Dominique, Calvez Vincent
Abstract excerpt
It has been shown that virological protease inhibitor (PI) resistance mutations present at the initiation of saquinavir (SQV) plus ritonavir (RTV) therapy in PI-experienced patients are the strongest predictors of virological response. But most of the current resistance algorithms are adapted for unboosted SQV regimens. We applied a stepwise methodology for the development and validation of a clinically relevant...
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