Article
Plasma drug levels, genotypic resistance, and virological response to a nelfinavir plus saquinavir-containing regimen.
AIDS (London, England) - 4 Jan 2002
Casado Jose L, Moreno Santiago, Hertogs Kurt, Dronda Fernando, Antela Antonio, Dehertogh Pascale, Perez-Elías María J, Moreno Ana
Abstract excerpt
OBJECTIVE: To determine the importance of resistance and drug levels in the response to a dual-protease inhibitor (PI) combination. METHODS: Prospective study of 62 HIV-positive patients who switched to a salvage regimen including nelfinavir plus saquinavir. Virological response was defined as a decrease in viraemia > 0.5 log10 after 24 weeks. Optimal PI levels were defined as those above the protein...
Topics
- Adult
- Aged
- Anti-HIV Agents
- Drug Resistance, Viral
- Drug Therapy, Combination
- Female
- Genotype
- HIV Infections
- HIV Protease
- HIV-1
- Humans