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Article

Emergence of resistant variants of HIV in vivo during monotherapy with the proteinase inhibitor saquinavir.

The Journal of antimicrobial chemotherapy - 1 Jun 1997

Ives K J, Jacobsen H, Galpin S A, Garaev M M, Dorrell L, Mous J, Bragman K, Weber J N

Abstract excerpt

We examined the phenotypic and genotypic properties of virus from the peripheral blood mononuclear cells (PBMC) and plasma of eight HIV-1-infected asymptomatic patients before and during monotherapy with the proteinase inhibitor saquinavir. Susceptibility of primary isolates to drug was assessed in PBMC culture by deriving IC50 and IC90 values. The observed increases in IC50 and IC90 after approximately one year...

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Identifiers

PMID: 9222047
DOI: 10.1093/jac/39.6.771

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Emergence of resistant variants of HIV in vivo during monotherapy with the proteinase inhibitor saquinavir.PMID 9222047Read ↗

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