Article
Emergence of resistant variants of HIV in vivo during monotherapy with the proteinase inhibitor saquinavir.
The Journal of antimicrobial chemotherapy - 1 Jun 1997
Ives K J, Jacobsen H, Galpin S A, Garaev M M, Dorrell L, Mous J, Bragman K, Weber J N
Abstract excerpt
We examined the phenotypic and genotypic properties of virus from the peripheral blood mononuclear cells (PBMC) and plasma of eight HIV-1-infected asymptomatic patients before and during monotherapy with the proteinase inhibitor saquinavir. Susceptibility of primary isolates to drug was assessed...
Topics
- Adult
- Anti-HIV Agents
- DNA Primers
- Drug Resistance
- Genes, gag
- Genes, pol
- HIV
- HIV Infections
- HIV Protease Inhibitors
- Humans
- Middle Aged
- Molecular Sequence Data
- Mutation
- Polymerase Chain Reaction
- Saquinavir
- Sequence Homology, Amino Acid