Analysis of pfmdr1 and drug susceptibility in fresh isolates of Plasmodium falciparum from subsaharan Africa.

doi:10.1016/0166-6851(95)02492-1

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Article

Analysis of pfmdr1 and drug susceptibility in fresh isolates of Plasmodium falciparum from subsaharan Africa.

Molecular and biochemical parasitology - 1 Nov 1995

Basco L K, Le Bras J, Rhoades Z, Wilson C M

Abstract excerpt

Resistance of Plasmodium falciparum to many therapeutic agents is an increasing problem in most endemic areas. The role of the mdr-like gene products of P. falciparum in resistance to quinoline-containing compounds is not clear. The purpose of this study was to further examine the role of pfmdr1 in drug resistance in fresh clinical isolates originating from Africa. Drug susceptibility testing (chloroquine,...

Topics

Africa South of the Sahara
Alleles
Animals
Antimalarials
Base Sequence
Chloroquine
Codon
DNA Fingerprinting
DNA, Protozoan
Drug Resistance, Multiple
Genes, Protozoan

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Genetic Variation

Humans

Malaria, Falciparum

Mefloquine

Phenotype

Plasmodium falciparum

Source

Open in PubMed

Identifiers

PMID: 8719157
DOI: 10.1016/0166-6851(95)02492-1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-8719157-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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