Article
DNA sequence polymorphisms of the pfmdr1 gene and association of mutations with the pfcrt gene in Indian Plasmodium falciparum isolates.
Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases - 1 Aug 2014
Chauhan Kshipra, Pande Veena, Das Aparup
Abstract excerpt
Mutations in the Plasmodium falciparum multidrug resistance (pfmdr1) gene are known to provide compensatory fitness benefits to the chloroquine (CQ)-resistant malaria parasites and are often associated with specific mutations in the P. falciparum CQ resistant transporter (pfcrt) gene. Prevalence of the specific mutations in these two genes across different malaria endemic regions was mostly studies. However,...
Topics
- Gene Frequency
- Genotype
- Geography
- Haplotypes
- Humans
- India
- Linkage Disequilibrium
- Malaria, Falciparum
- Membrane Transport Proteins
- Molecular Sequence Data
- Multidrug Resistance-Associated Proteins
- Mutation
- Plasmodium falciparum