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Article

pfmdr1 amplification and fixation of pfcrt chloroquine resistance alleles in Plasmodium falciparum in Venezuela.

Antimicrobial agents and chemotherapy - 1 Apr 2010

Griffing Sean, Syphard Luke, Sridaran Sankar, McCollum Andrea M, Mixson-Hayden Tonya, Vinayak Sumiti, Villegas Leopoldo, Barnwell John W, Escalante Ananias A, Udhayakumar Venkatachalam

Abstract excerpt

Molecular tools are valuable for determining evolutionary history and the prevalence of drug-resistant malaria parasites. These tools have helped to predict decreased sensitivity to antimalarials and fixation of multidrug resistance genotypes in some regions. In order to assess how historical drug policies impacted Plasmodium falciparum in Venezuela, we examined molecular changes in genes associated with drug...

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PMID: 20145087
DOI: 10.1128/AAC.01243-09
PMCID: PMC2849383

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