pfmdr1 amplification and fixation of pfcrt chloroquine resistance alleles in Plasmodium falciparum in Venezuela.

doi:10.1128/AAC.01243-09

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Article

pfmdr1 amplification and fixation of pfcrt chloroquine resistance alleles in Plasmodium falciparum in Venezuela.

Antimicrobial agents and chemotherapy - 1 Apr 2010

Griffing Sean, Syphard Luke, Sridaran Sankar, McCollum Andrea M, Mixson-Hayden Tonya, Vinayak Sumiti, Villegas Leopoldo, Barnwell John W, Escalante Ananias A, Udhayakumar Venkatachalam

Abstract excerpt

Molecular tools are valuable for determining evolutionary history and the prevalence of drug-resistant malaria parasites. These tools have helped to predict decreased sensitivity to antimalarials and fixation of multidrug resistance genotypes in some regions. In order to assess how historical drug policies impacted Plasmodium falciparum in Venezuela, we examined molecular changes in genes associated with drug...

Topics

Alleles
Antimalarials
Base Sequence
Chloroquine
DNA Primers
DNA, Protozoan
Drug Resistance, Multiple
Evolution, Molecular
Gene Amplification
Gene Dosage

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Genes, Protozoan

Genotype

Haplotypes

Humans

Linkage Disequilibrium

Malaria, Falciparum

Membrane Transport Proteins

Microsatellite Repeats

Source

Open in PubMed Open full text

Identifiers

PMID: 20145087
DOI: 10.1128/AAC.01243-09
PMCID: PMC2849383

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-20145087-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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