Article
Efflux systems and increased trypanothione levels in arsenite-resistant Leishmania.
Experimental parasitology - 1 Nov 1997
Légaré D, Papadopoulou B, Roy G, Mukhopadhyay R, Haimeur A, Dey S, Grondin K, Brochu C, Rosen B P, Ouellette M
Abstract excerpt
The mechanism of resistance to the metal arsenite has been studied and compared in L. mexicana, L. tropica, and L. tarentolae selected in a step by step manner for arsenite resistance. Amplification of the ABC transporter gene pgpA was found to be a frequent resistance mechanism in all species. T...
Topics
- ATP-Binding Cassette Transporters
- Animals
- Arsenites
- Biological Transport
- Drug Resistance
- Gene Amplification
- Glutathione
- Leishmania
- Leishmania mexicana
- Leishmania tropica
- Membrane Glycoproteins
- Models, Biological
- Mutation
- Protozoan Proteins
- Species Specificity