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Article

A preliminary study of apolipoprotein E genotype and psychiatric manifestations of Alzheimer's disease.

Neurology - 1 Jul 1996

Ramachandran G, Marder K, Tang M, Schofield P W, Chun M R, Devanand D P, Stern Y, Mayeux R

Abstract excerpt

We evaluated the frequency of depression and psychosis in 46 patients with AD and 135 control subjects with the apolipoprotein (APO) E3/3 or E3/4 genotype. Patients with AD and the APOE3/4 genotype had a more than threefold increase in the signs of depression and psychosis when compared with either patients with the APOE3/3 genotype or to control subjects. Our preliminary study suggests that the phenotype of AD...

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Identifiers

PMID: 8710089
DOI: 10.1212/wnl.47.1.256

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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