Structural and functional dissection of Sec62p, a membrane-bound component of the yeast endoplasmic reticulum protein import machinery.

doi:10.1128/mcb.10.11.6024-6035.1990

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Article

Structural and functional dissection of Sec62p, a membrane-bound component of the yeast endoplasmic reticulum protein import machinery.

Molecular and cellular biology - 1 Nov 1990

Deshaies R J, Schekman R

Abstract excerpt

SEC62 is required for the import of secretory protein precursors into the endoplasmic reticulum (ER) of Saccharomyces cerevisiae. The DNA sequence of SEC62 predicts a 32-kDa polypeptide with two potential membrane-spanning segments. Two antisera directed against different portions of the SEC62 co...

Topics

Cell Membrane
Endoplasmic Reticulum
Fungal Proteins
Genes, Fungal
Genes, Suppressor
Intracellular Membranes
Membrane Proteins
Phenotype
Plasmids
Saccharomyces cerevisiae

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