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Article

Characterization of the renal phenotype of transgenic rats expressing the human endothelin-2 gene.

Hypertension (Dallas, Tex. : 1979) - 1 Aug 1996

Hocher B, Liefeldt L, Thöne-Reineke C, Orzechowski H D, Distler A, Bauer C, Paul M

Abstract excerpt

We have previously established a transgenic rat model termed TGR(hET-2)37 overexpressing the human endothelin-2 (ET-2) gene with high renal transgene expression. This renal overexpression is of pathophysiological interest because a long-term activated paracrine renal endothelin system has been implicated in chronic renal failure due to progressive glomerular injury. Therefore, our aim in the present study was to...

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PMID: 8707381
DOI: 10.1161/01.hyp.28.2.196

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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