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Article

Purification and molecular cloning of Plx1, a Cdc25-regulatory kinase from Xenopus egg extracts.

Science (New York, N.Y.) - 6 Sept 1996

Kumagai A, Dunphy W G

Abstract excerpt

Cdc2, the cyclin-dependent kinase that controls mitosis, is negatively regulated by phosphorylation on its threonine-14 and tyrosine-15 residues. Cdc25, the phosphatase that dephosphorylates both of these residues, undergoes activation and phosphorylation by multiple kinases at mitosis. Plx1, a kinase that associates with and phosphorylates the amino-terminal domain of Cdc25, was purified extensively from Xenopus...

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Source

Identifiers

PMID: 8703070
DOI: 10.1126/science.273.5280.1377

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Purification and molecular cloning of Plx1, a Cdc25-regulatory kinase from Xenopus egg extracts.PMID 8703070Read ↗

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