Article
Functional homology among human and fission yeast Cdc14 phosphatases.
The Journal of biological chemistry - 12 Aug 2005
Vázquez-Novelle M Dolores, Esteban Verónica, Bueno Avelino, Sacristán María P
Abstract excerpt
Budding and fission yeast Cdc14 homologues, a conserved family of serine-threonine phosphatases, play a role in the inactivation of mitotic cyclin-dependent kinases (CDKs) by molecularly distinct mechanisms. Saccharomyces cerevisiae Cdc14 protein phosphatase inactivates CDKs by promoting mitotic cyclin degradation and the accumulation of a CDK inhibitor to allow budding yeast cells to exit from mitosis....
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