Cell cycle analysis and chromosomal localization of human Plk1, a putative homologue of the mitotic kinases <i>Drosophila</i> polo and <i>Saccharomyces cerevisiae</i> Cdc5

Abstract excerpt

polo and CDC5 are two genes required for passage through mitosis in Drosophila melanogaster and Saccharomyces cerevisiae, respectively. Both genes encode structurally related protein kinases that have been implicated in regulating the function of the mitotic spindle. Here, we report the characterization of a human protein kinase that displays extensive sequence similarity to Drosophila polo and S. cerevisiae...

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