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Article

Dopaminergic signalling and behavioural alterations by Comt-Dtnbp1 genetic interaction and their clinical relevance.

British journal of pharmacology - 1 Oct 2023

Managò Francesca, Scheggia Diego, Pontillo Maria, Mereu Maddalena, Mastrogiacomo Rosa, Udayan Gayatri, Valentini Paola, Tata Maria Cristina, Weinberger Daniel R, Weickert Cynthia S, Pompa Pier Paolo, De Luca Maria A, Vicari Stefano, Papaleo Francesco

Abstract excerpt

BACKGROUND AND PURPOSE: Cognitive and motor functions are modulated by dopaminergic signalling, which is shaped by several genetic factors. The biological effects of single genetic variants might differ depending on epistatic interactions that can be functionally multi-directional and non-linear. EXPERIMENTAL APPROACH: We performed behavioural and neurochemical assessments in genetically modified mice and...

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PMID: 37218669
DOI: 10.1111/bph.16147

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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