Immunosuppressant target protein FKBP12 is required for P-glycoprotein function in yeast.

doi:10.1074/jbc.271.31.18527

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Article

Immunosuppressant target protein FKBP12 is required for P-glycoprotein function in yeast.

The Journal of biological chemistry - 2 Aug 1996

Hemenway C S, Heitman J

Abstract excerpt

The mammalian P-glycoprotein (Pgp) is a approximately 170-kDa membrane protein that mediates multidrug resistance in many chemotherapy-resistant tumors by effluxing toxic compounds from the cell. Pgp homologs are expressed in many organisms, from bacteria to yeast and mammals. Previous studies es...

Topics

ATP Binding Cassette Transporter, Subfamily B, Member 1
Amino Acid Isomerases
Animals
Calcineurin
Calmodulin-Binding Proteins
Carrier Proteins
Cyclosporine
DNA-Binding Proteins
Dactinomycin
Drug Resistance, Multiple
Heat-Shock Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Humans

Immunosuppressive Agents

Methyltransferases

Mice

Mutation

Peptidylprolyl Isomerase

Phosphoprotein Phosphatases

Source

Open in PubMed

Identifiers

PMID: 8702500
DOI: 10.1074/jbc.271.31.18527

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-8702500-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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Immunosuppressant target protein FKBP12 is required for P-glycoprotein function in yeast.PMID 8702500Read ↗

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