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Article

Immunosuppressant target protein FKBP12 is required for P-glycoprotein function in yeast.

The Journal of biological chemistry - 2 Aug 1996

Hemenway C S, Heitman J

Abstract excerpt

The mammalian P-glycoprotein (Pgp) is a approximately 170-kDa membrane protein that mediates multidrug resistance in many chemotherapy-resistant tumors by effluxing toxic compounds from the cell. Pgp homologs are expressed in many organisms, from bacteria to yeast and mammals. Previous studies established a model system to analyze the function of murine, human, and Plasmodium falciparum Pgp by heterologous...

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Identifiers

PMID: 8702500
DOI: 10.1074/jbc.271.31.18527

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

Immunosuppressant target protein FKBP12 is required for P-glycoprotein function in yeast.PMID 8702500Read ↗

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Antifungal properties of the immunosuppressant FK-506: identification of an FK-506-responsive yeast gene distinct from FKB1.Semantic proximity Read ↗

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Fungal ATP-binding cassette (ABC) transporters in drug resistance & detoxification.Semantic proximity Read ↗

FKBP12 controls aspartate pathway flux in Saccharomyces cerevisiae to prevent toxic intermediate accumulation.Semantic proximity Read ↗

A novel screening for inhibitors of a pleiotropic drug resistant pump, Pdr5, in Saccharomyces cerevisiae.Semantic proximity Read ↗

Screening the yeast "disruptome" for mutants affecting resistance to the immunosuppressive drug, mycophenolic acid.Semantic proximity Read ↗

Dominant missense mutations in a novel yeast protein related to mammalian phosphatidylinositol 3-kinase and VPS34 abrogate rapamycin cytotoxicity.Semantic proximity Read ↗

ABC Transporters in Saccharomyces cerevisiae and Their Interactors: New Technology Advances the Biology of the ABCC (MRP) SubfamilySemantic proximity Read ↗

Targets for cell cycle arrest by the immunosuppressant rapamycin in yeast.Semantic proximity Read ↗

Hmo1p, a high mobility group 1/2 homolog, genetically and physically interacts with the yeast FKBP12 prolyl isomerase.Semantic proximity Read ↗

FKBP12-Dependent Inhibition of Calcineurin Mediates Immunosuppressive Antifungal Drug Action in MalasseziaSemantic proximity Read ↗

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