Article
Hmo1p, a high mobility group 1/2 homolog, genetically and physically interacts with the yeast FKBP12 prolyl isomerase.
Genetics - 1 Mar 1999
Dolinski K J, Heitman J
Abstract excerpt
The immunosuppressive drugs FK506 and rapamycin bind to the cellular protein FKBP12, and the resulting FKBP12-drug complexes inhibit signal transduction. FKBP12 is a ubiquitous, highly conserved, abundant enzyme that catalyzes a rate-limiting step in protein folding: peptidyl-prolyl cis-trans isomerization. However, FKBP12 is dispensible for viability in both yeast and mice, and therefore does not play an...
Topics
- Alleles
- Blotting, Western
- Dimerization
- Fungal Proteins
- Genetic Testing
- Glucose
- High Mobility Group Proteins
- Immunophilins
- Leucine
- Models, Biological
- Mutagenesis
- Orotic Acid
- Phenotype
- Receptors, Formyl Peptide
- Receptors, Immunologic