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Article

FKBP12 controls aspartate pathway flux in Saccharomyces cerevisiae to prevent toxic intermediate accumulation.

Eukaryotic cell - 1 Oct 2004

Arévalo-Rodríguez Miguel, Pan Xuewen, Boeke Jef D, Heitman Joseph

Abstract excerpt

FKBP12 is a conserved member of the prolyl-isomerase enzyme family and serves as the intracellular receptor for FK506 that mediates immunosuppression in mammals and antimicrobial actions in fungi. To investigate the cellular functions of FKBP12 in Saccharomyces cerevisiae, we employed a high-throughput assay to identify mutations that are synthetically lethal with a mutation in the FPR1 gene, which encodes...

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Identifiers

PMID: 15470257
DOI: 10.1128/EC.3.5.1287-1296.2004
PMCID: PMC522611

Genes

FPR1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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