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Article

Expression of the human acute myeloid leukemia gene AML1 is regulated by two promoter regions.

5 Mar 1996

Abstract excerpt

The human chromosome 21 AML1 gene is expressed predominantly in the hematopoietic system. In several leukemia-associated translocations AML1 is fused to other genes and transcription of the fused regions is mediated by upstream sequences that normally regulate the expression of AML1. The 5' genomic region of AML1 was cloned and sequenced. The two 5' untranslated regions (UTRs) previously identified in AML1 cDNAs...

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PMID: 8700862
DOI: 10.1073/pnas.93.5.1935

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