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Article

Functional characterization of ETV6 and ETV6/CBFA2 in the regulation of the MCSFR proximal promoter.

Proceedings of the National Academy of Sciences of the United States of America - 4 Mar 1997

Fears S, Gavin M, Zhang D E, Hetherington C, Ben-David Y, Rowley J D, Nucifora G

Abstract excerpt

The ETV6/CBFA2 (TEL/AML1) fusion gene occurs as a result of the chromosome translocation t(12;21)(p13;q22) in up to 30% of children diagnosed with B cell precursor (cd10+, cd19+) acute lymphoblastic leukemia. Leukemic cells that have acquired the t(12;21) usually demonstrate loss of the remaining...

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Topics

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Share to Binding Sites
Share to DNA-Binding Proteins
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Promoter Regions, Genetic

Source

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Identifiers

PMID: 9050885
DOI: 10.1073/pnas.94.5.1949
PMCID: PMC20023

Genes

ETV6
ETS1
FLI1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-9050885-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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