Article
Transcriptional Auto-Regulation of RUNX1 P1 Promoter.
PloS one - 1 Jan 2016
Martinez Milka, Hinojosa Marcela, Trombly Daniel, Morin Violeta, Stein Janet, Stein Gary, Javed Amjad, Gutierrez Soraya E
Abstract excerpt
RUNX1 a member of the family of runt related transcription factors (RUNX), is essential for hematopoiesis. The expression of RUNX1 gene is controlled by two promoters; the distal P1 promoter and the proximal P2 promoter. Several isoforms of RUNX1 mRNA are generated through the use of both promoters and alternative splicing. These isoforms not only differs in their temporal expression pattern but also exhibit...
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