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Article

Repression of vascular endothelial growth factor expression by the runt-related transcription factor 1 in acute myeloid leukemia.

Cancer research - 1 Apr 2011

Ter Elst Arja, Ma Bin, Scherpen Frank J G, de Jonge Hendrik J M, Douwes Jenny, Wierenga Albertus T J, Schuringa Jan Jacob, Kamps Willem A, de Bont Eveline S J M

Abstract excerpt

VEGFA is considered one of the most important regulators of tumor-associated angiogenesis in cancer. In acute myeloid leukemia (AML) VEGFA is an independent prognostic factor for reduced overall and relapse-free survival. Transcriptional activation of the VEGFA promoter, a core mechanism for VEGFA regulation, has not been fully elucidated. We found a significant (P < 0.0001) inverse correlation between expression...

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Share to Chromosomes, Human, Pair 21
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 21447743
DOI: 10.1158/0008-5472.CAN-10-0402

Genes

VEGFA
RUNX1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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