Article
The E-box motif in the proximal ABCA1 promoter mediates transcriptional repression of the ABCA1 gene.
Journal of lipid research - 1 Feb 2002
Yang Xiao-Ping, Freeman Lita A, Knapper Catherine L, Amar Marcelo J A, Remaley Alan, Brewer H Bryan, Santamarina-Fojo Silvia
Abstract excerpt
To identify regulatory elements in the proximal human ATP-binding cassette transporter A1 (hABCA1) gene promoter we transfected RAW cells with plasmids containing mutations in the E-box, AP1, and liver X receptor (LXR) elements as well as the two Sp1 motifs. Point mutations in either Sp1 site or in the AP1 site had only a minor effect whereas mutation of the LXR element decreased promoter activity. In contrast,...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.