Article
DNA sequence analysis of hprt mutations in lymphocytes from Sprague-Dawley rats treated with 7,12-dimethylbenz[a]anthracene.
Environmental and molecular mutagenesis - 1 Jan 1996
Heflich R H, Mittelstaedt R A, Manjanatha M G, Lyn-Cook L E, Aidoo A
Abstract excerpt
Treatment of female Sprague-Dawley rats with the potent mammary gland carcinogen 7,12-dimethylbenz[a]anthracene (DMBA) results in the formation of DNA adducts with dG and dA and in the induction of 6-thioguanine-resistant (TGr) lymphocyte mutants. In this study, we have examined the types of muta...
Topics
- 9,10-Dimethyl-1,2-benzanthracene
- Animals
- Base Sequence
- Carcinogens
- DNA
- DNA Mutational Analysis
- Exons
- Female
- Hypoxanthine Phosphoribosyltransferase
- Introns
- Lymphocytes
- Molecular Sequence Data
- Mutation
- Rats
- Rats, Sprague-Dawley