Article
Comparison of induction of hprt mutations by 1,3-butadiene and/or its metabolites 1,2-epoxybutene and 1,2,3,4-diepoxybutane in lymphocytes from spleen of adult male mice and rats in vivo.
Mutation research - 16 Jan 1998
Tates A D, van Dam F J, van Teylingen C M, de Zwart F A, Zwinderman A H
Abstract excerpt
Induction of hprt mutations by 1,3-butadiene (BD) and its metabolites 1,2-epoxybutene (EB) and 1,2,3,4-diepoxybutane (DEB) was studied in lymphocytes from spleens of 6- to 14-week-old mice and 10- to 11-week-old rats. For unknown reasons, results from experiments with mice that received inhalatio...
Topics
- Age Factors
- Animals
- Butadienes
- Cells, Cultured
- Clone Cells
- Enzyme Induction
- Epoxy Compounds
- Ethylnitrosourea
- Hypoxanthine Phosphoribosyltransferase
- Lymphocytes
- Male
- Mice
- Mice, Inbred Strains
- Mutagens
- Mutation
- Rats
- Rats, Inbred Lew
- Spleen