Promiscuous and allele-specific anchors in HLA-DR-binding peptides.

doi:10.1016/0092-8674(93)90306-b

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Article

Promiscuous and allele-specific anchors in HLA-DR-binding peptides.

Cell - 16 Jul 1993

Hammer J, Valsasnini P, Tolba K, Bolin D, Higelin J, Takacs B, Sinigaglia F

Abstract excerpt

The major histocompatibility complex (MHC) class II molecules are highly polymorphic membrane glycoproteins that bind peptide fragments of proteins and display them for recognition by CD4+ T cells. To understand the effect of human MHC class II polymorphism on peptide-MHC interaction, we have iso...

Topics

Alleles
Amino Acid Sequence
Bacteriophage M13
Binding Sites
HLA-DR Antigens
Humans
Molecular Sequence Data
Peptides
Sequence Alignment

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