Genetic analysis of long-term Barrett's esophagus epithelial cultures exhibiting cytogenetic and ploidy abnormalities.

doi:10.1016/s0016-5085(98)70480-9

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Article

Genetic analysis of long-term Barrett's esophagus epithelial cultures exhibiting cytogenetic and ploidy abnormalities.

Gastroenterology - 1 Feb 1998

Palanca-Wessels M C, Barrett M T, Galipeau P C, Rohrer K L, Reid B J, Rabinovitch P S

Abstract excerpt

BACKGROUND & AIMS: Progression to cancer in Barrett's esophagus occurs through an accumulation of cell cycle and genetic abnormalities that have been documented in vivo. To better study neoplastic evolution in Barrett's esophagus, the aim of this study was to establish in vitro cultures from pren...

Topics

Adult
Aged
Aged, 80 and over
Barrett Esophagus
Cell Culture Techniques
Cell Division
Cyclin-Dependent Kinase Inhibitor p16
DNA
Epithelial Cells
Female
Genes, p53
Humans
Karyotyping
Loss of Heterozygosity
Male
Middle Aged
Mutation
Ploidies

Source

Open in PubMed

Identifiers

PMID: 9453489
DOI: 10.1016/s0016-5085(98)70480-9

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-9453489-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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