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Article

Genetic analysis of long-term Barrett's esophagus epithelial cultures exhibiting cytogenetic and ploidy abnormalities.

Gastroenterology - 1 Feb 1998

Palanca-Wessels M C, Barrett M T, Galipeau P C, Rohrer K L, Reid B J, Rabinovitch P S

Abstract excerpt

BACKGROUND & AIMS: Progression to cancer in Barrett's esophagus occurs through an accumulation of cell cycle and genetic abnormalities that have been documented in vivo. To better study neoplastic evolution in Barrett's esophagus, the aim of this study was to establish in vitro cultures from preneoplastic tissues. METHODS: Mechanical and enzymatic dissociation methods were used to initiate Barrett's epithelial...

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PMID: 9453489
DOI: 10.1016/s0016-5085(98)70480-9

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