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Article

A structural model for the HAT domain of Utp6 incorporating bioinformatics and genetics.

Protein engineering, design & selection : PEDS - 1 Jul 2009

Champion Erica A, Kundrat Lenka, Regan Lynne, Baserga Susan J

Abstract excerpt

The half-a-tetratricopeptide (HAT) repeat motif is of interest because it is found exclusively in proteins that are involved in RNA metabolism. Little is known about structure-function relationships in this class of repeat motif. Here, we present the results of a combined bioinformatics, modeling and mutagenesis study of the HAT domain of Utp6. We have derived a new HAT consensus, delineated its...

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Identifiers

PMID: 19515729
DOI: 10.1093/protein/gzp022
PMCID: PMC2699269

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