Article
The degree of variation in DNA sequence recognition among four Drosophila homeotic proteins.
The EMBO journal - 1 Aug 1994
Ekker S C, Jackson D G, von Kessler D P, Sun B I, Young K E, Beachy P A
Abstract excerpt
The homeodomain has been implicated as a major determinant of biological specificity for the homeotic selector (HOM) genes. We compare here the DNA sequence preferences of homeodomains encoded by four of the eight Drosophila HOM proteins. One of the four, Abdominal-B, binds preferentially to a sequence with an unusual 5'-T-T-A-T-3' core, whereas the other three prefer 5'-T-A-A-T-3'. Of these latter three, the...
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