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Article

Specific DNA recognition by the Antp homeodomain: MD simulations of specific and nonspecific complexes.

Proteins - 1 Dec 2004

Gutmanas Aleksandras, Billeter Martin

Abstract excerpt

Four molecular dynamics simulation trajectories of complexes between the wild-type or a mutant Antennapedia homeodomain and 2 DNA sequences were generated in order to probe the mechanisms governing the specificity of DNA recognition. The starting point was published affinity measurements showing that a single protein mutation combined with a replacement of 2 base pairs yields a new high-affinity complex, whereas...

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Identifiers

PMID: 15468320
DOI: 10.1002/prot.20273

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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