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Development of new molecular procedures for the detection of genetic alterations in man.

Mutation research - 12 Jun 1996

Steingrimsdottir H, Beare D, Cole J, Leal J F, Kostic T, Lopez-Barea J, Dorado G, Lehmann A R

Abstract excerpt

The Restriction Site Mutation (RSM) procedure is a DNA-based method for detecting mutations at any unselected locus. Mutations are identified as alterations of the DNA sequence at a chosen restriction site. DNA from cells exposed to mutagenic treatment is exhaustively digested with the restriction enzyme (RE). Sequences containing the mutated target site are specifically amplified using the polymerase chain...

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PMID: 8692187
DOI: 10.1016/0027-5107(95)00244-8

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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