Article
The detection of mutations induced in vitro in the human p53 gene by hydrogen peroxide with the restriction site mutation (RSM) assay.
Mutation research - 15 Nov 2001
Jenkins G J, Morgan C, Baxter J N, Parry E M, Parry J M
Abstract excerpt
We have analysed five mutation hotspots within the p53 gene (codons 175, 213, 248, 249, and 282) for mutations induced by hydrogen peroxide (H(2)O(2)), employing the restriction site mutation (RSM) assay. In addition, four other restriction sites covering non-hotspot codons of exons 5-9 of the p53 gene (codons 126, 153/54, 189 and the 3' splice site of exon 9) were analysed by the RSM assay for H(2)O(2)-induced...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.