Restriction site mutation analysis, a proposed methodology for the detection and study of DNA base changes following mutagen exposure.

doi:10.1093/mutage/5.3.209

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Article

Restriction site mutation analysis, a proposed methodology for the detection and study of DNA base changes following mutagen exposure.

Mutagenesis - 1 May 1990

Parry J M, Shamsher M, Skibinski D O

Abstract excerpt

We propose a methodology for the detection of DNA base changes in restriction enzyme recognition sites. The restriction site mutation (RSM) technique is based upon the detection of DNA sequences resistant to the cutting action of specific restriction enzymes and the amplification of these resista...

Topics

Animals
Base Sequence
Cricetinae
DNA
Deoxyribonucleases
Genes, ras
Mesocricetus
Molecular Sequence Data
Mutagens
Mutation
Polymerase Chain Reaction
Restriction Mapping

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