Article
Restriction site mutation analysis, a proposed methodology for the detection and study of DNA base changes following mutagen exposure.
Mutagenesis - 1 May 1990
Parry J M, Shamsher M, Skibinski D O
Abstract excerpt
We propose a methodology for the detection of DNA base changes in restriction enzyme recognition sites. The restriction site mutation (RSM) technique is based upon the detection of DNA sequences resistant to the cutting action of specific restriction enzymes and the amplification of these resistant sequences using the polymerase chain reaction. As outlined, the RSM method has the potential for use in the study of...
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