Article
Nuk controls pathfinding of commissural axons in the mammalian central nervous system.
Cell - 12 Jul 1996
Henkemeyer M, Orioli D, Henderson J T, Saxton T M, Roder J, Pawson T, Klein R
Abstract excerpt
Eph family receptor tyrosine kinases have been proposed to control axon guidance and fasciculation. To address the biological functions of the Eph family member Nuk, two mutations in the mouse germline have been generated: a protein null allele (Nuk1) and an allele that encodes a Nuk-beta gal fusion receptor lacking the tyrosine kinase and C-terminal domains (Nuk(lacZ)). In Nuk1 homozygous brains, the majority of...
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