Article
The Drosophila Wnt5 protein mediates selective axon fasciculation in the embryonic central nervous system.
Developmental biology - 15 Aug 2004
Fradkin Lee G, van Schie Martijn, Wouda Rene R, de Jong Anja, Kamphorst Jessica T, Radjkoemar-Bansraj Monique, Noordermeer Jasprina N
Abstract excerpt
The decision of whether and where to cross the midline, an evolutionarily conserved line of bilateral symmetry in the central nervous system, is the first task for many newly extending axons. We show that Wnt5, a member of the conserved Wnt secreted glycoprotein family, is required for the formation of the anterior of the two midline-crossing commissures present in each Drosophila hemisegment. Initial path...
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