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Neuronal Neuregulin 1 type III directs Schwann cell migration

30 Sept 2011

Abstract excerpt

During peripheral nerve development, each segment of a myelinated axon is matched with a single Schwann cell. Tight regulation of Schwann cell movement, proliferation and differentiation is essential to ensure that these glial cells properly associate with axons. ErbB receptors are required for Schwann cell migration, but the operative ligand and its mechanism of action have remained unknown. We demonstrate that...

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PMID: 21965611
DOI: 10.1242/dev.068072

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Related research

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