Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Role of Postreplicative DNA Mismatch Repair in the Cytotoxic Action of Thioguanine

23 Aug 1996

Abstract excerpt

It is proposed here that the delayed cytotoxicity of thioguanine involves the postreplicative DNA mismatch repair system. After incorporation into DNA, the thioguanine is chemically methylated by S-adenosylmethionine to form S6-methylthioguanine. During DNA replication, the S6-methylthioguanine directs incorporation of either thymine or cytosine into the growing DNA strand, and the resultant...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cancer Genomics and Diagnostics
Share to DNA Repair Mechanisms
Share to Genetic factors in colorectal cancer

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 8688098
DOI: 10.1126/science.273.5278.1109

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Role of Postreplicative DNA Mismatch Repair in the Cytotoxic Action of ThioguaninePMID 8688098Read ↗

Thiopurines, DNA damage, DNA repair and therapy-related cancerSemantic proximity Read ↗

Mechanisms of carcinogenicity/chemotherapy by O6-methylguanineSemantic proximity Read ↗

Multiple forms of DNA Damage Caused by UVA Photoactivation of DNA 6‐ThioguanineSemantic proximity Read ↗

Mutagenic and cytotoxic properties of 6-thioguanine, S6-methylthioguanine, and guanine-S6-sulfonic acid.Semantic proximity Read ↗

Genomic instability and tolerance to alkylating agents.Semantic proximity Read ↗

Mechanism of mutagenesis by O6-methylguanine.Semantic proximity Read ↗

Repair of O4-alkylthymine damage in human cells.Semantic proximity Read ↗

Methoxyamine modification of abasic sites protects CHO cells from the cytotoxic and mutagenic effects of oxygen alkylation.Semantic proximity Read ↗

Mutations in human O6-alkylguanine-DNA alkyltransferase imparting resistance to O6-benzylguanine.Semantic proximity Read ↗

X-ray induction of O6-alkylguanine-DNA alkyltransferase protects against some of the biological effects of N-methyl-N'-nitro-N-nitrosoguanidine in C3H 10T1/2 cells.Semantic proximity Read ↗

Azathioprine treatment photosensitizes human skin to ultraviolet A radiationSemantic proximity Read ↗

Mutagenic consequences of the incorporation of 6-thioguanine into DNA.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.