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Azathioprine: old drug, new actions

15 Apr 2003

Abstract excerpt

A knowledge of the biochemical loci of action of 6-MP in the inhibition of nucleic acid synthesis is not sufficient to explain the effects of the thiopurines on the immune system. —Gertrude B. Elion (Winner of 1988 Nobel Prize in Medicine for “important principals of drug development”; codiscovered 6-MP and azathioprine with George Hitchings) (1) Azathioprine is among the oldest pharmacologic...

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PMID: 12697731
DOI: 10.1172/jci18384

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Azathioprine: old drug, new actionsPMID 12697731Read ↗

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