Multiple forms of DNA Damage Caused by UVA Photoactivation of DNA 6‐Thioguanine

doi:10.1111/j.1751-1097.2011.01043.x

Article

Multiple forms of DNA Damage Caused by UVA Photoactivation of DNA 6‐Thioguanine

12 Nov 2011

Abstract excerpt

Thiopurines are prescribed frequently as medication for cancer and for inflammatory disorders. One of them, azathioprine, has been the immunosuppressant of choice for organ transplant recipients for many years. Thiopurine use is associated with elevated sun sensitivity and skin cancer risk. Skin sensitization is selective for UVA. 6-TG integrates into DNA and unlike the canonical DNA bases, it is a strong UVA...

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