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Article

Multiple-sited interaction of caldesmon with Ca(2+)-calmodulin.

The Biochemical journal - 1 Jun 1996

Huber P A, El-Mezgueldi M, Grabarek Z, Slatter D A, Levine B A, Marston S B

Abstract excerpt

The binding of Ca(2+)- and Ba(2+)-calmodulin to caldesmon and its functional consequence was investigated with three different calmodulin mutants. Two calmodulin mutants have pairs of cysteine residues substituted and oxidized to a disulphide bond in either the N- or C-terminal lobe (C41/75 and C85/112). The third mutant has phenylalanine-92 replaced by alanine (F92A). Binding measurements in the presence of Ca2+...

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PMID: 8687382
DOI: 10.1042/bj3160413
PMCID: PMC1217366

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